High-speed rail to Naples or Salerno, then Intercity direct to Reggio.
High-speed rail does not yet reach Reggio, but the HS + Intercity combination covers the journey efficiently.
From Milan, Turin, Bologna, Florence: High-speed to Naples, then Intercity or overnight service to Reggio (4–5h).
The Trenitalia night train departs in the evening and arrives at Reggio Calabria Centrale in the morning.
Travellers from Sicily take the train to Messina, cross the Strait by ferry, and continue by train to Reggio.
From Bari Centrale via Taranto along the Ionian coastal line to Reggio. Longer but scenic along the Ionian Sea.